Die Treibhausgas-Reduzierungsziele der Europäischen Union bedingen weitreichende Transformationen innerhalb des gesamten Energiesystems. The use of hydrogen is a promising option for decarbonization, especially in industrial processes. Due to the influence of various dynamic factors (future energy demand, climate impacts, etc.) in conjunction with a less flexible and cost-intensive pipeline system, the planning for the initial development of such a regional hydrogen infrastructure represents a major challenge and is not possible with today’s network planning tools. In order to solve the challenge described above, the doctoral thesis will show how a regional hydrogen infrastructure consisting of generation plants, pipeline networks and various supply systems can be set up, taking into account the requirements for sustainable spatial development. This will happen in the format of modeling the hydrogen infrastructure in the Sauerland region, taking into account spatial suitability and resistance analyses. Points relating to the security of supply of energy infrastructure are also linked to the concept of sustainability in spatial planning in order to further develop the interdisciplinary understanding of sustainability. Based on the results of scenario analyses and the resulting hydrogen infrastructure planning for the region, general guidelines for grid planning are formulated to support the development of sustainable energy infrastructure in the future.